Brain Health Project

From Bedside to Bench to Bedside
Brain Project Summary

Biology of Brain Aging and Applied Preventative Clinical Practice: Individualized Mechanistic Medicine and it's Measurement

Established Alzheimer’s disease cannot be cured

It is biologically and pharmacologically implausible

Genes vs their "workhorses, proteins

The scientific basis for the molecular biology of brain aging has been clearly defined

Lifestyle, Nutrition and Exercise

Factors involved requiring interventions with multiple physiologic / pharmacologicactions including lifestyle, nutrition and exercise.

Supplements, Medical Foods and Drugs

The FDA has classified /defined three categories of preventative/therapeutic agents:supplements; medical foods; drugs

Oral Cognitive Enhancers (OCE)

Functional medical foods for promotion of brain health.

CogniFemme, CogniHomme and CogniTrans

Formulation of CogniFemme ( women ); CogniHomme (men) CogniTrans (gender neutral)

Comparing Proven Biomarkers

Monitoring efficacy by blood biomarkers as surrogate measures of brain health and function. Comparing proven biomarkers with less expensive tests: CogniAchE (surrogate for beta amyloid/tau protein brain accumulation ); CogniReserve (BDNF/AchE ratio) a measure of cognitive reserve AND brain health.

Societal need and commercial opportunity

Currently there are a plethora of poorly researched brain health supplements but NO medical foods that replicate that of CF/CH/CT and theirproposed biomarkers, which are essential for long term compliance and when indicate, dosage adjustment.

Patents

Mechanistic Medicine : Maintaining the Physiology of Brain Aging by Modulation of the checks and balances of the multiple signaling pathways needed to prevent the age related changes associated with cognitive decline and Alzheimer's Disease.

Formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults

Prevention of age associated neurodegenerative changes resulting in cognitive, memory and executive dysfunction including modulation of the age related predisposition to mild cognitive impairment, Alzheimer’s disease, hormonal and other dementia related conditions

read more

Research

The Brain Health Project and it’s Patents were conceptualized by applying the same physiological and biological principles to numerous aspects of women’s health and where relevant by collaboration with basic scientists, the molecular basis for the clinical presentation and applied preventative practice : bedside to bench to bedside.

Window of Opportunity

Mammographic Density in Postmenopausal Women

Osteoporosis Prevention Diagnosis and Treatment

Climacteric Medicine

Hemostasis Research

Deveolping Birthing Centers

Type II Diabetes in Young Pregnant and Non-Pregnant Women

read more